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The
FDA has approved two medications, sibutramine and orlistat, for long-term
use in the treatment of obesity. Sibutramine (sold under the brand
name Meridia) increases fullness, making the
required dietary changes for weight loss and the maintenance of
weight loss easier to accomplish. Orlistat (sold under the brand name
Xenical) works by blocking the absorption of fat. Scientists are also
investigating the hormone leptin, which plays a role in obesity in
mice, as a possible treatment for obesity in humans.
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